The medicines which are used to cure disease of digestive system /part 2/proton pump inhibitors /

In this video you can watch following important knowledge of medicine which are used in digestive system-
1.mechanism action of proton pump inhibitors.
2.mechanism action of ulcer protective drugs.
3.mechanism action of specific antidiarrheals'.

Proton pump inhibitors act by irreversibly blocking the hydrogen/potassium adenosine triphosphatase enzyme system (the H+/K+ ATPase, or more commonly gastric proton pump) of the gastric parietal cells. The proton pump is the terminal stage in gastric acid secretion, being directly responsible for secreting H+ ions into the gastric lumen, making it an ideal target for inhibiting acid secretion.

The efficacy of gastric acid suppressive drugs, such as histamine H2-receptor antagonists and H+K+ ATPase inhibitors, in the management of peptic ulcer diseases has been well established. They accelerate the healing of peptic ulcers, and maintenance therapy with these drugs prevents ulcer relapse.

HOW DO ANTIDIARRHEALS WORK?
Antidiarrheals are a class of medications used to treat acute and chronic diarrhea. Antidiarrheals help to reduce the frequency and urgency of passing stools; however, they do not eliminate the cause of diarrhea, and hence, diarrhea will occur as soon as you stop the antidiarrheal medications until the underlying cause (such as infection or inflammation) is treated properly.

Diarrhea is a common problem and usually lasts for a couple of days, whether treatment is taken or not; however, antidiarrheals will help you feel better, especially if you have cramping pains. It can be caused by:

Bacteria and parasites
Viruses
Medications such as antibiotics
Lactose intolerance (inability to digest lactose, the main carbohydrate in dairy)
Food allergies
Digestive disorders (irritable bowel syndrome, celiac disease, Crohn’s disease.
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